导师风采
姜宏
-
女
-
学院：健康与生命科学院
-
职称：教授
-
学科名称：神经生物学
-
专业领域：神经退行性疾病的病因及其防治对策
-
学习与工作经历：
2001.9-2004.7 青岛大学生理学博士
2007.1-2008.1 美国Sun Health Research Institute博士后
2000.7-2022.9 青岛大学 讲师，副教授，教授，博导
2022.9-至今 康复大学 领导小组成员，教授，博导
研究方向：
（1）神经退行性疾病发病机制及早期诊断研究；
（2）神经退行性疾病蛋白质及转录组学研究；
（3）神经退行性疾病康复治疗与技术。
学术/社会兼职：
教育部新世纪优秀人才，山东省泰山学者特聘专家，山东省杰青，中国神经科学学会常务理事，中国生理学会常务理事，中国高等教育学会医学教育专业委员会常务理事，中国神经科学学会神经内稳态和内分泌分会委员等
获奖荣誉：
山东省科学技术进步奖二等奖，首位
青岛市科学技术奖一等奖，首位
山东省自然科学二等奖，第二位
青岛市自然科学一等奖，第二位
山东省科技二等奖，首位
本科生课程：
生理科学进展 40学时
生理科学前沿进展 40学时
生物学专业英语 6学时
1.AGTR1对黑质铁代谢调控的新机制及在帕金森病中的作用，国家自然科学基金面上项目，32371013，2024.01-2027.12，50万，主持。
2.α-突触核蛋白经延髓-脑桥-黑质通路传播在帕金森病病程进展中的作用机制研究，国家自然科学基金面上项目，32171131，2022.01-2025.12，58万，主持。
3.基于帕金森病铁沉积和蛋白质聚集的靶标研究与海洋药物研发，山东省重点研发计划（重大科技创新工程），2021ZDSYS11，2021.12-2024.12，200万，主持。
4.去泛素化酶OTUD3参与帕金森病黑质多巴胺能神经元死亡的分子机制研究，山东省自然科学基金重大基础研究项目，ZR2019ZD31，2019.12-2024.12，177万，主持。
1. Xiao X, Bi M, Du X*, Jiang H*. The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration? Expert Opin Ther Targets. 2023 Jul;27(7):517-521.
2. Tang T, Bi M, Diao M, Zhang X, Chen L, Xiao X, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease mouse model through activating GHS-R1a/D2R heterodimer. Acta Pharmacol Sin. 2023 Aug;44(8):1564-1575.
3. Chen L, Huan X, Jia F, Zhang Z, Bi M, Fu L, Du X, Chen X, Yan C, Jiao Q*, Jiang H*. Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis. Antioxidants (Basel). 2023 Mar 26;12(4):809.
4. Chen L, Bi M, Zhang Z, Du X, Chen X, Jiao Q*, Jiang H*. The functions of IRE1α in neurodegenerative diseases: Beyond ER stress. Ageing Res Rev. 2022 Dec:82:101774.
5. Liu Y#, Wang W#, Song N#, Jiao J, Jia F, Du X, Chen X, Yan C, Jiao J, Jiao Q*, Jiang H*. Ghrelin bridges DMV neuropathology and GI dysfunction in the early stages of Parkinson's disease. Adv Sci (Weinh). 2022 Oct;9(30):e2203020.
6. Dang X, Huan X, Du X, Chen X, Bi M, Yan C, Jiao Q*, Jiang H*. Correlation of ferroptosis and other types of cell death in neurodegenerative diseases. Neurosci Bull. 2022 Aug;38(8):938-952.
7. Lv J, Xiao X, Bi M, Tang T, Kong D, Diao M, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. ATP-sensitive potassium channels: a double-edged sword in neurodegenerative diseases. Ageing Res Rev. 2022 Jun 17;101676.
8. Liu M#, Liu C#, Xiao X, Han S, Bi M, Jiao Q, Chen X, Yan C, Du X*, Jiang H*. Role of upregulation of the KATP channel subunit SUR1 in dopaminergic neuron degeneration in Parkinson’s disease. Aging Cell. 2022 May;21(5):e13618.
9. Jia F#, Li H#, Jiao Q, Li C, Fu L, Cui C, Jiang H*, Zhang L*. Deubiquitylase OTUD3 prevents Parkinson’s disease through stabilizing iron regulatory protein 2. Cell Death Dis. 2022 Apr 30;13(4):418.
10. Chen X, Dong J, Jiao Q, Du X, Bi M, Jiang H*. “Sibling” Battle or Harmony: Crosstalk between Nesfatin-1 and Ghrelin. Cell Mol Life Sci. 2022 Mar 3;79(3):169.
11. Wang W, Su L, Ji F, Zhang D, Wang Y, Zhao J, Jiao R, Zhang M, Huang E, Jiang H*, Zhang J*, Jiao J*. EMBO Rep. 2022 Feb 3;23(3):e53602.
12. Yao Z, Fu L, Jia F, Bi M, Jiao Q, Chen X, Du X, Jiang H*. Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism. Ageing Res Rev. 2022 Jan:73:101511.
13. Liu M, Jiao Q, Du X, Bi M, Chen X*, Jiang H*. The potential crosstalk between Parkinson’s Disease and Energy Metabolism, Aging Dis. 2021 Dec 1;12(8):2003-2015.
14. Zhang J#, Liu H#, Jiang H*. Commentary: Dopamine-Dependent Early Synaptic and Motor Dysfunctions Induced by a-Synuclein in the Nigrostriatal Circuit. Front Aging Neurosci. 2021 Nov 29:13:790224.
15. Dong X, Jiang H*, Li S, Zhang D*. Low Serum Testosterone Concentrations Are Associated With Poor Cognitive Performance in Older Men but Not Women. Front Aging Neurosci. 2021 Nov 1;13:712237.
16. Bi M, Du X, Xiao X, Dai D, Jiao Q, Chen X, Zhang L, Jiang H*. Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease, Redox Biol, 2021 Nov:47:102167.
17. Zhao Q, Li Y, Du X, Chen X, Jiao Q*, Jiang H*. Effects of deubiquitylases on the biological behaviors of neural stem cells. Dev Neurobiol. 2021 Sep;81(6):847-858.
18. Jiao L, Du X, Jia F, Li Y, Zhu D, Tang T, Jiao Q*, Jiang H*. Early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in Parkinson's disease mice. Neurobiol Aging. 2021 May;101:70-78.
19. Gai W, Peng Z, Liu C, Zhang L*, Jiang H*. Advances in Cancer Treatment by Targeting the Neddylation Pathway. Front Cell Dev Biol. 2021 Apr; 8;9:653882.
20. Bi M, Du X, Jiao Q, Chen X, Jiang H*. Expanding the role of proteasome homeostasis in Parkinson's disease: beyond protein breakdown. Cell Death Dis. 2021 Feb 4;12(2):154.
